Lineage-specific and single cell chromatin accessibility charts human hematopoiesis and leukemia evolution

We define the chromatin accessibility and transcriptional landscapes in thirteen human primary blood cell types that traverse the hematopoietic hierarchy. Exploiting the finding that the enhancer landscape better reflects cell identity than mRNA levels, we enable “enhancer cytometry” for enumeration...

Descripción completa

Detalles Bibliográficos
Autores principales: Corces, M. Ryan, Buenrostro, Jason D., Wu, Beijing, Greenside, Peyton G., Chan, Steven M., Koenig, Julie L., Snyder, Michael P., Pritchard, Jonathan K., Kundaje, Anshul, Greenleaf, William J., Majeti, Ravindra, Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042844/
https://www.ncbi.nlm.nih.gov/pubmed/27526324
http://dx.doi.org/10.1038/ng.3646

Ejemplares similares

Ejemplares similares