Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer

Sustained expression of the oestrogen receptor alpha (ESR1) drives two-thirds of breast cancer and defines the ESR1-positive subtype. ESR1 engages enhancers upon oestrogen stimulation to establish an oncogenic expression program(1). Somatic copy number alterations involving the ESR1 gene occur in ap...

Descripción completa

Detalles Bibliográficos
Autores principales: Bailey, Swneke D., Desai, Kinjal, Kron, Ken J., Mazrooei, Parisa, Sinnott-Armstrong, Nicholas A., Treloar, Aislinn E., Dowar, Mark, Thu, Kelsie L., Cescon, David W., Silvester, Jennifer, Yang, S. Y. Cindy, Wu, Xue, Pezo, Rossanna C., Haibe-Kains, Benjamin, Mak, Tak W., Bedard, Philippe L., Pugh, Trevor J., Sallari, Richard C., Lupien, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042848/
https://www.ncbi.nlm.nih.gov/pubmed/27571262
http://dx.doi.org/10.1038/ng.3650

Ejemplares similares

Ejemplares similares