Weaponizing human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) for 21(st) century cancer therapeutics

De-regulated EFEMP1 gene expression in solid tumors has been widely reported with conflicting roles. We dissected EFEMP1 to identify domains responsible for its cell context-dependent dual functions, with the goal being to construct an EFEMP1-derived tumor-suppressor protein (ETSP) that lacked tumor...

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Detalles Bibliográficos
Autores principales: Zhou, Yi-Hong, Hu, Yuanjie, Yu, Liping, Ke, Chao, Vo, Christopher, Hsu, Hao, Li, Zhenzhi, Di Donato, Anne T., Chaturbedi, Abhishek, Hwang, Ji Won, Siegel, Eric R., Linskey, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043071/
https://www.ncbi.nlm.nih.gov/pubmed/27713911
http://dx.doi.org/10.18632/oncoscience.306

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