An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase

Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorpti...

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Autores principales: Tchesnokov, E. P., Faponle, A. S., Davies, C. G., Quesne, M. G., Turner, R., Fellner, M., Souness, R. J., Wilbanks, S. M., de Visser, S. P., Jameson, G. N. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043143/
https://www.ncbi.nlm.nih.gov/pubmed/27297454
http://dx.doi.org/10.1039/c6cc03904a
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author Tchesnokov, E. P.
Faponle, A. S.
Davies, C. G.
Quesne, M. G.
Turner, R.
Fellner, M.
Souness, R. J.
Wilbanks, S. M.
de Visser, S. P.
Jameson, G. N. L.
author_facet Tchesnokov, E. P.
Faponle, A. S.
Davies, C. G.
Quesne, M. G.
Turner, R.
Fellner, M.
Souness, R. J.
Wilbanks, S. M.
de Visser, S. P.
Jameson, G. N. L.
author_sort Tchesnokov, E. P.
collection PubMed
description Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.
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spelling pubmed-50431432016-10-12 An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase Tchesnokov, E. P. Faponle, A. S. Davies, C. G. Quesne, M. G. Turner, R. Fellner, M. Souness, R. J. Wilbanks, S. M. de Visser, S. P. Jameson, G. N. L. Chem Commun (Camb) Chemistry Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm. Royal Society of Chemistry 2016-07-21 2016-06-09 /pmc/articles/PMC5043143/ /pubmed/27297454 http://dx.doi.org/10.1039/c6cc03904a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Tchesnokov, E. P.
Faponle, A. S.
Davies, C. G.
Quesne, M. G.
Turner, R.
Fellner, M.
Souness, R. J.
Wilbanks, S. M.
de Visser, S. P.
Jameson, G. N. L.
An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
title An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
title_full An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
title_fullStr An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
title_full_unstemmed An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
title_short An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
title_sort iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043143/
https://www.ncbi.nlm.nih.gov/pubmed/27297454
http://dx.doi.org/10.1039/c6cc03904a
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