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The physiological role of the brain GLP-1 system in stress

Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associate...

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Autores principales: Holt, Marie K., Trapp, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cogent 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043148/
https://www.ncbi.nlm.nih.gov/pubmed/27722184
http://dx.doi.org/10.1080/23312025.2016.1229086
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author Holt, Marie K.
Trapp, Stefan
author_facet Holt, Marie K.
Trapp, Stefan
author_sort Holt, Marie K.
collection PubMed
description Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism’s motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been found to be activated in response to stressful stimuli. The source of GLP-1 within the brain, the preproglucagon (PPG) neurons, are ideally situated in the brainstem to receive and relay signals of stress and our recent data on the projection pattern of the PPG neurons to the spinal cord suggest a potential strong link with the sympathetic nervous system. We review here the role of central GLP-1 in the regulation of stress responses and discuss the potential involvement of the endogenous source of GLP-1 within the brain, the PPG neurons.
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spelling pubmed-50431482016-10-06 The physiological role of the brain GLP-1 system in stress Holt, Marie K. Trapp, Stefan Cogent Biol Review Article Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism’s motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been found to be activated in response to stressful stimuli. The source of GLP-1 within the brain, the preproglucagon (PPG) neurons, are ideally situated in the brainstem to receive and relay signals of stress and our recent data on the projection pattern of the PPG neurons to the spinal cord suggest a potential strong link with the sympathetic nervous system. We review here the role of central GLP-1 in the regulation of stress responses and discuss the potential involvement of the endogenous source of GLP-1 within the brain, the PPG neurons. Cogent 2016-12-31 2016-09-14 /pmc/articles/PMC5043148/ /pubmed/27722184 http://dx.doi.org/10.1080/23312025.2016.1229086 Text en © 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license http://creativecommons.org/licenses/by/4.0/ You are free to: Share — copy and redistribute the material in any medium or format. Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. No additional restrictions You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
spellingShingle Review Article
Holt, Marie K.
Trapp, Stefan
The physiological role of the brain GLP-1 system in stress
title The physiological role of the brain GLP-1 system in stress
title_full The physiological role of the brain GLP-1 system in stress
title_fullStr The physiological role of the brain GLP-1 system in stress
title_full_unstemmed The physiological role of the brain GLP-1 system in stress
title_short The physiological role of the brain GLP-1 system in stress
title_sort physiological role of the brain glp-1 system in stress
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043148/
https://www.ncbi.nlm.nih.gov/pubmed/27722184
http://dx.doi.org/10.1080/23312025.2016.1229086
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