Cargando…

Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer’s Disease

Neurofibrillary tangles composed of aggregates of hyperphosphorylated tau proteins are one of the neuropathological hallmarks of Alzheimer’s disease (AD) in addition to the deposition of β-amyloid plaques. Since the deposition of tau aggregates is closely associated with the severity of AD, the in v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ono, Masahiro, Watanabe, Hiroyuki, Kitada, Ayane, Matsumura, Kenji, Ihara, Masafumi, Saji, Hideo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043239/ https://www.ncbi.nlm.nih.gov/pubmed/27687137 http://dx.doi.org/10.1038/srep34197

Ejemplares similares

Novel PET/SPECT Probes for Imaging of Tau in Alzheimer's Disease
por: Watanabe, Hiroyuki, et al.
Publicado: (2015)

Aluminum and Tau in Neurofibrillary Tangles in Familial Alzheimer’s Disease
por: Mold, Matthew John, et al.
Publicado: (2021)

Fluent molecular mixing of Tau isoforms in Alzheimer’s disease neurofibrillary tangles
por: Dregni, Aurelio J., et al.
Publicado: (2022)

Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease
por: Miyashita, A, et al.
Publicado: (2014)

The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
por: Hondius, David C., et al.
Publicado: (2021)

Development of Novel (123)I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer’s Disease
por: Ono, Masahiro, et al.
Publicado: (2013)

Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics
por: Metaxas, Athanasios, et al.
Publicado: (2016)

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
por: Bryan, Kathryn J, et al.
Publicado: (2008)

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer’s disease
por: Wang, Chunyu, et al.
Publicado: (2016)

Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles
por: Hunter, Sally, et al.
Publicado: (2015)

Entorhinal Subfield Vulnerability to Neurofibrillary Tangles in Aging and the Preclinical Stage of Alzheimer’s Disease
por: Llamas-Rodríguez, Josué, et al.
Publicado: (2022)

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2021)

Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer’s disease()
por: Stouffer, Kaitlin M., et al.
Publicado: (2023)

The Homologous Carboxyl-Terminal Domains of Microtubule-Associated Protein 2 and TAU Induce Neuronal Dysfunction and Have Differential Fates in the Evolution of Neurofibrillary Tangles
por: Xie, Ce, et al.
Publicado: (2014)

Inside Alzheimer brain with CLARITY: senile plaques, neurofibrillary tangles and axons in 3-D
por: Ando, Kunie, et al.
Publicado: (2014)

Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer’s Disease and Related Neurological Disorders
por: Mold, Matthew John, et al.
Publicado: (2020)

Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer’s Disease
por: Furcila, Diana, et al.
Publicado: (2019)

Visualization of neurofibrillary tangle maturity in Alzheimer's disease: A clinicopathologic perspective for biomarker research
por: Moloney, Christina M., et al.
Publicado: (2021)

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)

Human TAU(P301L) overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain
por: Cosacak, Mehmet I., et al.
Publicado: (2017)

In vivo quantification of neurofibrillary tangles with [(18)F]MK-6240
por: Pascoal, Tharick A., et al.
Publicado: (2018)

Phosphatidylinositol-4,5-bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles
por: Nishikawa, Tomokazu, et al.
Publicado: (2014)

Clinical Neuropathology image 5-2016: neurofibrillary tangle-rich ganglioglioma
por: Gelpi, Ellen, et al.
Publicado: (2016)

Braak neurofibrillary tangle staging prediction from in vivo MRI metrics
por: Dallaire-Théroux, Caroline, et al.
Publicado: (2019)

Association of Neighborhood-Level Disadvantage With Neurofibrillary Tangles on Neuropathological Tissue Assessment
por: Powell, W. Ryan, et al.
Publicado: (2022)

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer’s disease patients
por: Michael, Ralph, et al.
Publicado: (2017)

Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer’s disease
por: Ohm, Daniel T., et al.
Publicado: (2020)

Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease
por: Kiper, Keturah, et al.
Publicado: (2022)

Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands
por: Rafique, Waqas, et al.
Publicado: (2018)

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles
por: Kaeser, Stephan A., et al.
Publicado: (2021)

Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain
por: Cox, Paul Alan, et al.
Publicado: (2016)

Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies
por: Chibnik, Lori B, et al.
Publicado: (2017)

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain
por: Fadul, Motaz M., et al.
Publicado: (2020)

Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment
por: Marx, Gabriel A., et al.
Publicado: (2022)

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice
por: Jaworski, Tomasz, et al.
Publicado: (2009)

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
por: Ahmed, Zeshan, et al.
Publicado: (2014)

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles
por: Qi, Yao, et al.
Publicado: (2020)

Novel Bivalent (99m)Tc-Complex with N-Methyl-Substituted Hydroxamamide as Probe for Imaging of Cerebral Amyloid Angiopathy
por: Iikuni, Shimpei, et al.
Publicado: (2016)

A Histochemical Analysis of Neurofibrillary Tangles in Olfactory Epithelium, a Study Based on an Autopsy Case of Juvenile Alzheimer’s Disease
por: Shimizu, Shino, et al.
Publicado: (2022)

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease
por: Zhang, Zhentao, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_sfq1ifkk7uis9viji4aq96o31l