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Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour

INTRODUCTION: Tumours with adenocarcinoma and neuroendocrine components have often been reported, although the reason underlying the dual components remains unclear. CASE PRESENTATION: A 43-year-old woman with multiple liver metastatic lesions of rectal neuroendocrine tumour underwent primary tumour...

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Autores principales: Ishii, Norihiro, Araki, Kenichiro, Yokobori, Takehiko, Tsukagoshi, Mariko, Igarashi, Takamichi, Watanabe, Akira, Kubo, Norio, Hirai, Keitaro, Shirabe, Ken, Kuwano, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043256/
https://www.ncbi.nlm.nih.gov/pubmed/27721729
http://dx.doi.org/10.1159/000446641
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author Ishii, Norihiro
Araki, Kenichiro
Yokobori, Takehiko
Tsukagoshi, Mariko
Igarashi, Takamichi
Watanabe, Akira
Kubo, Norio
Hirai, Keitaro
Shirabe, Ken
Kuwano, Hiroyuki
author_facet Ishii, Norihiro
Araki, Kenichiro
Yokobori, Takehiko
Tsukagoshi, Mariko
Igarashi, Takamichi
Watanabe, Akira
Kubo, Norio
Hirai, Keitaro
Shirabe, Ken
Kuwano, Hiroyuki
author_sort Ishii, Norihiro
collection PubMed
description INTRODUCTION: Tumours with adenocarcinoma and neuroendocrine components have often been reported, although the reason underlying the dual components remains unclear. CASE PRESENTATION: A 43-year-old woman with multiple liver metastatic lesions of rectal neuroendocrine tumour underwent primary tumour resection and subsequent liver transplantation. Pathological examination indicated a cholangiocarcinoma-like tumour with gland formation, adjacent to a liver metastatic lesion of the neuroendocrine tumour. This tumour comprised atypical columnar epithelium, and stained positively for neuroendocrine markers and the ductal marker cytokeratin 19, indicating amphicrine properties and a partial cholangiocarcinoma phenotype – features not observed in the primary and metastatic neuroendocrine tumours. CONCLUSION: The presence of adenocarcinoma only at the metastatic site indicated that neuroendocrine tumour cells acquired stemness and differentiated into adenocarcinoma through metastasis, or that the adenocarcinoma newly arose from the adjacent epithelium influenced by the neuroendocrine tumour. We propose a novel mechanism for the pathogenesis of mixed tumours in neuroendocrine tumours.
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spelling pubmed-50432562016-10-07 Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour Ishii, Norihiro Araki, Kenichiro Yokobori, Takehiko Tsukagoshi, Mariko Igarashi, Takamichi Watanabe, Akira Kubo, Norio Hirai, Keitaro Shirabe, Ken Kuwano, Hiroyuki Case Rep Gastroenterol Case Report INTRODUCTION: Tumours with adenocarcinoma and neuroendocrine components have often been reported, although the reason underlying the dual components remains unclear. CASE PRESENTATION: A 43-year-old woman with multiple liver metastatic lesions of rectal neuroendocrine tumour underwent primary tumour resection and subsequent liver transplantation. Pathological examination indicated a cholangiocarcinoma-like tumour with gland formation, adjacent to a liver metastatic lesion of the neuroendocrine tumour. This tumour comprised atypical columnar epithelium, and stained positively for neuroendocrine markers and the ductal marker cytokeratin 19, indicating amphicrine properties and a partial cholangiocarcinoma phenotype – features not observed in the primary and metastatic neuroendocrine tumours. CONCLUSION: The presence of adenocarcinoma only at the metastatic site indicated that neuroendocrine tumour cells acquired stemness and differentiated into adenocarcinoma through metastasis, or that the adenocarcinoma newly arose from the adjacent epithelium influenced by the neuroendocrine tumour. We propose a novel mechanism for the pathogenesis of mixed tumours in neuroendocrine tumours. S. Karger AG 2016-08-12 /pmc/articles/PMC5043256/ /pubmed/27721729 http://dx.doi.org/10.1159/000446641 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Ishii, Norihiro
Araki, Kenichiro
Yokobori, Takehiko
Tsukagoshi, Mariko
Igarashi, Takamichi
Watanabe, Akira
Kubo, Norio
Hirai, Keitaro
Shirabe, Ken
Kuwano, Hiroyuki
Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour
title Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour
title_full Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour
title_fullStr Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour
title_full_unstemmed Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour
title_short Presence of Cytokeratin 19-Expressing Cholangiocarcinoma-Like Tumour in a Liver Metastatic Lesion of Rectal Neuroendocrine Tumour
title_sort presence of cytokeratin 19-expressing cholangiocarcinoma-like tumour in a liver metastatic lesion of rectal neuroendocrine tumour
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043256/
https://www.ncbi.nlm.nih.gov/pubmed/27721729
http://dx.doi.org/10.1159/000446641
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