Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus

Diverse pathogenic agents often utilize overlapping host networks, and hub proteins within these networks represent attractive targets for broad-spectrum drugs. Using bacterial toxins, we describe a new approach for discovering broad-spectrum therapies capable of inhibiting host proteins that mediat...

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Detalles Bibliográficos
Autores principales: Leonardi, William, Zilbermintz, Leeor, Cheng, Luisa W., Zozaya, Josue, Tran, Sharon H., Elliott, Jeffrey H., Polukhina, Kseniya, Manasherob, Robert, Li, Amy, Chi, Xiaoli, Gharaibeh, Dima, Kenny, Tara, Zamani, Rouzbeh, Soloveva, Veronica, Haddow, Andrew D., Nasar, Farooq, Bavari, Sina, Bassik, Michael C., Cohen, Stanley N., Levitin, Anastasia, Martchenko, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043268/
https://www.ncbi.nlm.nih.gov/pubmed/27686742
http://dx.doi.org/10.1038/srep34475

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