Identification of DNA methylation changes associated with disease progression in subchondral bone with site-matched cartilage in knee osteoarthritis

Subchondral bone plays a key role in the development of osteoarthritis, however, epigenetics of subchondral bone has not been extensively studied. In this study, we examined the genome-wide DNA methylation profiles of subchondral bone from three regions on tibial plateau representing disease progres...

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Detalles Bibliográficos
Autores principales: Zhang, Yanfei, Fukui, Naoshi, Yahata, Mitsunori, Katsuragawa, Yozo, Tashiro, Toshiyuki, Ikegawa, Shiro, Lee, Ming Ta Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043275/
https://www.ncbi.nlm.nih.gov/pubmed/27686527
http://dx.doi.org/10.1038/srep34460

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