Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma

There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble...

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Autores principales: Chehimi, Mohamad, Boone, Mathieu, Chivot, Cyril, Deramond, Hervé, Constans, Jean-Marc, Ly, Mony Chenda, Chauffert, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043287/
https://www.ncbi.nlm.nih.gov/pubmed/27721775
http://dx.doi.org/10.1159/000448654
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author Chehimi, Mohamad
Boone, Mathieu
Chivot, Cyril
Deramond, Hervé
Constans, Jean-Marc
Ly, Mony Chenda
Chauffert, Bruno
author_facet Chehimi, Mohamad
Boone, Mathieu
Chivot, Cyril
Deramond, Hervé
Constans, Jean-Marc
Ly, Mony Chenda
Chauffert, Bruno
author_sort Chehimi, Mohamad
collection PubMed
description There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble drug could make the most of the first-pass effect. Here, we evaluated idarubicin (IDA), a lipophilic anthracycline, in an in vitro assay using four human GB cell lines and compared it with 11 other drugs previously used for the IA treatment of brain tumors. Despite impressive in vitro cytotoxicity, IA IDA did not produce a beneficial effect in 2 patients with recurrent GB.
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spelling pubmed-50432872016-10-07 Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma Chehimi, Mohamad Boone, Mathieu Chivot, Cyril Deramond, Hervé Constans, Jean-Marc Ly, Mony Chenda Chauffert, Bruno Case Rep Oncol Case Report There is no effective treatment for recurrent glioblastoma (GB) when temozolomide-based radiochemotherapy fails. In theory, intra-arterial (IA) delivery of cytotoxic agents could achieve higher drug concentrations in tumors compared to intravenous injection. Moreover, choosing a highly lipid-soluble drug could make the most of the first-pass effect. Here, we evaluated idarubicin (IDA), a lipophilic anthracycline, in an in vitro assay using four human GB cell lines and compared it with 11 other drugs previously used for the IA treatment of brain tumors. Despite impressive in vitro cytotoxicity, IA IDA did not produce a beneficial effect in 2 patients with recurrent GB. S. Karger AG 2016-08-30 /pmc/articles/PMC5043287/ /pubmed/27721775 http://dx.doi.org/10.1159/000448654 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Chehimi, Mohamad
Boone, Mathieu
Chivot, Cyril
Deramond, Hervé
Constans, Jean-Marc
Ly, Mony Chenda
Chauffert, Bruno
Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_full Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_fullStr Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_full_unstemmed Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_short Intra-Arterial Delivery of Idarubicin in Two Patients with Glioblastoma
title_sort intra-arterial delivery of idarubicin in two patients with glioblastoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043287/
https://www.ncbi.nlm.nih.gov/pubmed/27721775
http://dx.doi.org/10.1159/000448654
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