Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing

Alzheimer’s disease (AD) is the most prevalent form of dementia characterized by the extracellular accumulation of amyloid β (Aβ) peptides, which are produced by proteolytic cleavages of amyloid precursor protein (APP). Gangliosides are involved in AD pathophysiology including Aβ deposition and APP...

Descripción completa

Detalles Bibliográficos
Autores principales: Yamaguchi, Tokiaki, Yamauchi, Yoshio, Furukawa, Keiko, Ohmi, Yuhsuke, Ohkawa, Yuki, Zhang, Qing, Okajima, Tetsuya, Furukawa, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043288/
https://www.ncbi.nlm.nih.gov/pubmed/27687691
http://dx.doi.org/10.1038/srep34505

Ejemplares similares

Ejemplares similares