Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus

The PP2C family member Wild-type p53-induced phosphatase 1 (Wip1) critically regulates DNA damage response (DDR) under stressful situations. In the present study, we investigated whether Wip1 expression was involved in the regulation of DDR-induced and depression-related cellular senescence in mouse...

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Detalles Bibliográficos
Autores principales: He, Zhi-Yong, Wang, Wen-Yue, Hu, Wei-Yan, Yang, Lu, Li, Yan, Zhang, Wei-Yuan, Yang, Ya-Shu, Liu, Si-Cheng, Zhang, Feng-Lan, Mei, Rong, Xing, Da, Xiao, Zhi-Cheng, Zhang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043360/
https://www.ncbi.nlm.nih.gov/pubmed/27686532
http://dx.doi.org/10.1038/srep34558

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