The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake

The anti-atherogenic cytokine TGF-β inhibits macrophage foam cell formation by suppressing the expression of key genes implicated in the uptake of modified lipoproteins. We have previously shown a critical role for p38 MAPK and JNK in the TGF-β-mediated regulation of apolipoprotein E expression in h...

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Detalles Bibliográficos
Autores principales: Salter, Rebecca C., Foka, Pelagia, Davies, Thomas S., Gallagher, Hayley, Michael, Daryn R., Ashlin, Tim G., Ramji, Dipak P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043369/
https://www.ncbi.nlm.nih.gov/pubmed/27687241
http://dx.doi.org/10.1038/srep34368

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