A pre-metazoan origin of the CRK gene family and co-opted signaling network

CRK and CRKL adapter proteins play essential roles in development and cancer through their SRC homology 2 and 3 (SH2 and SH3) domains. To gain insight into the origin of their shared functions, we have investigated their evolutionary history. We propose a term, crk/crkl ancestral (crka), for ortholo...

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Detalles Bibliográficos
Autores principales: Shigeno-Nakazawa, Yoko, Kasai, Takuma, Ki, Sewon, Kostyanovskaya, Elina, Pawlak, Jana, Yamagishi, Junya, Okimoto, Noriaki, Taiji, Makoto, Okada, Mariko, Westbrook, Jody, Satta, Yoko, Kigawa, Takanori, Imamoto, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/
https://www.ncbi.nlm.nih.gov/pubmed/27686861
http://dx.doi.org/10.1038/srep34349

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