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Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome

Motivational signals influence a wide variety of cognitive processes and components of behavioral performance. Cognitive dysfunction in patients with childhood chronic fatigue syndrome (CCFS) may be closely associated with a low motivation to learn induced by impaired neural reward processing. Howev...

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Autores principales: Mizuno, Kei, Kawatani, Junko, Tajima, Kanako, Sasaki, Akihiro T., Yoneda, Tetsuya, Komi, Masanori, Hirai, Toshinori, Tomoda, Akemi, Joudoi, Takako, Watanabe, Yasuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043413/
https://www.ncbi.nlm.nih.gov/pubmed/27709065
http://dx.doi.org/10.1016/j.nicl.2016.09.016
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author Mizuno, Kei
Kawatani, Junko
Tajima, Kanako
Sasaki, Akihiro T.
Yoneda, Tetsuya
Komi, Masanori
Hirai, Toshinori
Tomoda, Akemi
Joudoi, Takako
Watanabe, Yasuyoshi
author_facet Mizuno, Kei
Kawatani, Junko
Tajima, Kanako
Sasaki, Akihiro T.
Yoneda, Tetsuya
Komi, Masanori
Hirai, Toshinori
Tomoda, Akemi
Joudoi, Takako
Watanabe, Yasuyoshi
author_sort Mizuno, Kei
collection PubMed
description Motivational signals influence a wide variety of cognitive processes and components of behavioral performance. Cognitive dysfunction in patients with childhood chronic fatigue syndrome (CCFS) may be closely associated with a low motivation to learn induced by impaired neural reward processing. However, the extent to which reward processing is impaired in CCFS patients is unclear. The aim of the present functional magnetic resonance imaging (fMRI) study was to determine whether brain activity in regions related to reward sensitivity is impaired in CCFS patients. fMRI data were collected from 13 CCFS patients (mean age, 13.6 ± 1.0 years) and 13 healthy children and adolescents (HCA) (mean age, 13.7 ± 1.3 years) performing a monetary reward task. Neural activity in high- and low-monetary-reward conditions was compared between CCFS and HCA groups. Severity of fatigue and the reward obtained from learning in daily life were evaluated by questionnaires. Activity of the putamen was lower in the CCFS group than in the HCA group in the low-reward condition, but not in the high-reward condition. Activity of the putamen in the low-reward condition in CCFS patients was negatively and positively correlated with severity of fatigue and the reward from learning in daily life, respectively. We previously revealed that motivation to learn was correlated with striatal activity, particularly the neural activity in the putamen. This suggests that in CCFS patients low putamen activity, associated with altered dopaminergic function, decreases reward sensitivity and lowers motivation to learn.
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spelling pubmed-50434132016-10-05 Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome Mizuno, Kei Kawatani, Junko Tajima, Kanako Sasaki, Akihiro T. Yoneda, Tetsuya Komi, Masanori Hirai, Toshinori Tomoda, Akemi Joudoi, Takako Watanabe, Yasuyoshi Neuroimage Clin Regular Article Motivational signals influence a wide variety of cognitive processes and components of behavioral performance. Cognitive dysfunction in patients with childhood chronic fatigue syndrome (CCFS) may be closely associated with a low motivation to learn induced by impaired neural reward processing. However, the extent to which reward processing is impaired in CCFS patients is unclear. The aim of the present functional magnetic resonance imaging (fMRI) study was to determine whether brain activity in regions related to reward sensitivity is impaired in CCFS patients. fMRI data were collected from 13 CCFS patients (mean age, 13.6 ± 1.0 years) and 13 healthy children and adolescents (HCA) (mean age, 13.7 ± 1.3 years) performing a monetary reward task. Neural activity in high- and low-monetary-reward conditions was compared between CCFS and HCA groups. Severity of fatigue and the reward obtained from learning in daily life were evaluated by questionnaires. Activity of the putamen was lower in the CCFS group than in the HCA group in the low-reward condition, but not in the high-reward condition. Activity of the putamen in the low-reward condition in CCFS patients was negatively and positively correlated with severity of fatigue and the reward from learning in daily life, respectively. We previously revealed that motivation to learn was correlated with striatal activity, particularly the neural activity in the putamen. This suggests that in CCFS patients low putamen activity, associated with altered dopaminergic function, decreases reward sensitivity and lowers motivation to learn. Elsevier 2016-09-26 /pmc/articles/PMC5043413/ /pubmed/27709065 http://dx.doi.org/10.1016/j.nicl.2016.09.016 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Mizuno, Kei
Kawatani, Junko
Tajima, Kanako
Sasaki, Akihiro T.
Yoneda, Tetsuya
Komi, Masanori
Hirai, Toshinori
Tomoda, Akemi
Joudoi, Takako
Watanabe, Yasuyoshi
Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome
title Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome
title_full Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome
title_fullStr Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome
title_full_unstemmed Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome
title_short Low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome
title_sort low putamen activity associated with poor reward sensitivity in childhood chronic fatigue syndrome
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043413/
https://www.ncbi.nlm.nih.gov/pubmed/27709065
http://dx.doi.org/10.1016/j.nicl.2016.09.016
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