Analysis of morphine responses in mice reveals a QTL on Chromosome 7

In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional cand...

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Detalles Bibliográficos
Autores principales: Crusio, Wim E., Dhawan, Esha, Chesler, Elissa J., Delprato, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043443/
https://www.ncbi.nlm.nih.gov/pubmed/27746909
http://dx.doi.org/10.12688/f1000research.9484.2
Descripción
Sumario:In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.

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