Analysis of morphine responses in mice reveals a QTL on Chromosome 7

In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional cand...

Descripción completa

Detalles Bibliográficos
Autores principales: Crusio, Wim E., Dhawan, Esha, Chesler, Elissa J., Delprato, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043443/
https://www.ncbi.nlm.nih.gov/pubmed/27746909
http://dx.doi.org/10.12688/f1000research.9484.2
_version_ 1782456759423598592
author Crusio, Wim E.
Dhawan, Esha
Chesler, Elissa J.
Delprato, Anna
author_facet Crusio, Wim E.
Dhawan, Esha
Chesler, Elissa J.
Delprato, Anna
author_sort Crusio, Wim E.
collection PubMed
description In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli.
format Online
Article
Text
id pubmed-5043443
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher F1000Research
record_format MEDLINE/PubMed
spelling pubmed-50434432016-10-13 Analysis of morphine responses in mice reveals a QTL on Chromosome 7 Crusio, Wim E. Dhawan, Esha Chesler, Elissa J. Delprato, Anna F1000Res Research Note In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. This QTL was revealed after correcting for the effects of another QTL peak on Chromosome 10 using composite interval mapping. The positional candidate genes are Syt9 and Ppfibp2. Several other genes within the interval are linked to neural processes, locomotor activity, and the defensive response to harmful stimuli. F1000Research 2016-10-27 /pmc/articles/PMC5043443/ /pubmed/27746909 http://dx.doi.org/10.12688/f1000research.9484.2 Text en Copyright: © 2016 Crusio WE et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Crusio, Wim E.
Dhawan, Esha
Chesler, Elissa J.
Delprato, Anna
Analysis of morphine responses in mice reveals a QTL on Chromosome 7
title Analysis of morphine responses in mice reveals a QTL on Chromosome 7
title_full Analysis of morphine responses in mice reveals a QTL on Chromosome 7
title_fullStr Analysis of morphine responses in mice reveals a QTL on Chromosome 7
title_full_unstemmed Analysis of morphine responses in mice reveals a QTL on Chromosome 7
title_short Analysis of morphine responses in mice reveals a QTL on Chromosome 7
title_sort analysis of morphine responses in mice reveals a qtl on chromosome 7
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043443/
https://www.ncbi.nlm.nih.gov/pubmed/27746909
http://dx.doi.org/10.12688/f1000research.9484.2
work_keys_str_mv AT crusiowime analysisofmorphineresponsesinmicerevealsaqtlonchromosome7
AT dhawanesha analysisofmorphineresponsesinmicerevealsaqtlonchromosome7
AT cheslerelissaj analysisofmorphineresponsesinmicerevealsaqtlonchromosome7
AT delpratoanna analysisofmorphineresponsesinmicerevealsaqtlonchromosome7

Ejemplares similares