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Polypyrrole-incorporated conductive hyaluronic acid hydrogels

BACKGROUND: Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological sys...

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Detalles Bibliográficos
Autores principales: Yang, Jongcheol, Choe, Goeun, Yang, Sumi, Jo, Hyerim, Lee, Jae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043520/
https://www.ncbi.nlm.nih.gov/pubmed/27708859
http://dx.doi.org/10.1186/s40824-016-0078-y
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author Yang, Jongcheol
Choe, Goeun
Yang, Sumi
Jo, Hyerim
Lee, Jae Young
author_facet Yang, Jongcheol
Choe, Goeun
Yang, Sumi
Jo, Hyerim
Lee, Jae Young
author_sort Yang, Jongcheol
collection PubMed
description BACKGROUND: Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited. METHOD: To create electrically conductive hydrogels, we fabricated composite hydrogels of hyaluronic acid and polypyrrole. In particular, we synthesized and used pyrrole-hyaluronic acid-conjugates and further chemically polymerized polypyrrole with the conjugates for the production of conductive hydrogels that can display suitable mechanical and structural properties. RESULTS: Various characterization methods, using a rheometer, a scanning electron microscope, and an electrochemical analyzer, revealed that the PPy/HA hydrogels were soft and conductive with ~ 3 kPa Young’s modulus and ~ 7.3 mS/cm conductivity. Our preliminary in vitro culture studies showed that fibroblasts were well attached and grew on the conductive hydrogels. CONCLUSION: These new conductive hydrogels will be greatly beneficial in fields of biomaterials in which electrical properties are important such as tissue engineering scaffolds and prosthetic devices.
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spelling pubmed-50435202016-10-05 Polypyrrole-incorporated conductive hyaluronic acid hydrogels Yang, Jongcheol Choe, Goeun Yang, Sumi Jo, Hyerim Lee, Jae Young Biomater Res Research Article BACKGROUND: Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited. METHOD: To create electrically conductive hydrogels, we fabricated composite hydrogels of hyaluronic acid and polypyrrole. In particular, we synthesized and used pyrrole-hyaluronic acid-conjugates and further chemically polymerized polypyrrole with the conjugates for the production of conductive hydrogels that can display suitable mechanical and structural properties. RESULTS: Various characterization methods, using a rheometer, a scanning electron microscope, and an electrochemical analyzer, revealed that the PPy/HA hydrogels were soft and conductive with ~ 3 kPa Young’s modulus and ~ 7.3 mS/cm conductivity. Our preliminary in vitro culture studies showed that fibroblasts were well attached and grew on the conductive hydrogels. CONCLUSION: These new conductive hydrogels will be greatly beneficial in fields of biomaterials in which electrical properties are important such as tissue engineering scaffolds and prosthetic devices. BioMed Central 2016-09-29 /pmc/articles/PMC5043520/ /pubmed/27708859 http://dx.doi.org/10.1186/s40824-016-0078-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yang, Jongcheol
Choe, Goeun
Yang, Sumi
Jo, Hyerim
Lee, Jae Young
Polypyrrole-incorporated conductive hyaluronic acid hydrogels
title Polypyrrole-incorporated conductive hyaluronic acid hydrogels
title_full Polypyrrole-incorporated conductive hyaluronic acid hydrogels
title_fullStr Polypyrrole-incorporated conductive hyaluronic acid hydrogels
title_full_unstemmed Polypyrrole-incorporated conductive hyaluronic acid hydrogels
title_short Polypyrrole-incorporated conductive hyaluronic acid hydrogels
title_sort polypyrrole-incorporated conductive hyaluronic acid hydrogels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043520/
https://www.ncbi.nlm.nih.gov/pubmed/27708859
http://dx.doi.org/10.1186/s40824-016-0078-y
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