Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I

Missense single-nucleotide polymorphisms (mSNPs) in titin are emerging as a main causative factor of heart failure. However, distinguishing between benign and disease-causing mSNPs is a substantial challenge. Here, we research the question of whether a single mSNP in a generic domain of titin can af...

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Detalles Bibliográficos
Autores principales: Bogomolovas, Julius, Fleming, Jennifer R., Anderson, Brian R., Williams, Rhys, Lange, Stephan, Simon, Bernd, Khan, Muzamil M., Rudolf, Rüdiger, Franke, Barbara, Bullard, Belinda, Rigden, Daniel J., Granzier, Henk, Labeit, Siegfried, Mayans, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043576/
https://www.ncbi.nlm.nih.gov/pubmed/27683155
http://dx.doi.org/10.1098/rsob.160114

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