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Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility

Cellular adaptation to hypoxia occurs via a complex programme of gene expression mediated by the hypoxia-inducible factor (HIF). The oxygen labile alpha subunits, HIF-1α/-2α, form a heterodimeric transcription factor with HIF-1β and modulate gene expression. HIF-1α and HIF-2α possess similar domain...

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Detalles Bibliográficos
Autores principales:	Taylor, S. E., Bagnall, J., Mason, D., Levy, R., Fernig, D. G., See, V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043584/ https://www.ncbi.nlm.nih.gov/pubmed/27655733 http://dx.doi.org/10.1098/rsob.160195

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