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Challenging perspectives on the cellular origins of lymphoma

Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon encountering antigen via this receptor or its...

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Detalles Bibliográficos
Autores principales: Malcolm, Tim I. M., Hodson, Daniel J., Macintyre, Elizabeth A., Turner, Suzanne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043587/
https://www.ncbi.nlm.nih.gov/pubmed/27683157
http://dx.doi.org/10.1098/rsob.160232
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author Malcolm, Tim I. M.
Hodson, Daniel J.
Macintyre, Elizabeth A.
Turner, Suzanne D.
author_facet Malcolm, Tim I. M.
Hodson, Daniel J.
Macintyre, Elizabeth A.
Turner, Suzanne D.
author_sort Malcolm, Tim I. M.
collection PubMed
description Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon encountering antigen via this receptor or its precursor, and they have the capacity to be extremely long lived as ‘memory’ cells. All three of these traits are fundamental to their ability to function as the adaptive immune response to infectious agents, but concurrently render these cells vulnerable to transformation. Thus, it is classically considered that lymphomas arise at a relatively late stage in a lymphocyte's development during the process of modifying diversity within antigen receptors, and when the cell is capable of responding to stimulus via its receptor. Attempts to understand the aetiology of lymphoma have reinforced this notion, as the most notable advances to date have shown chronic stimulation of the antigen receptor by infectious agents or self-antigens to be key drivers of these diseases. Despite this, there is still uncertainty about the cell of origin in some lymphomas, and increasing evidence that a subset arises in a more immature cell. Specifically, a recent study indicates that T-cell lymphoma, in particular nucleophosmin-anaplastic lymphoma kinase-driven anaplastic large cell lymphoma, may originate in T-cell progenitors in the thymus.
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spelling pubmed-50435872016-10-05 Challenging perspectives on the cellular origins of lymphoma Malcolm, Tim I. M. Hodson, Daniel J. Macintyre, Elizabeth A. Turner, Suzanne D. Open Biol Review Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon encountering antigen via this receptor or its precursor, and they have the capacity to be extremely long lived as ‘memory’ cells. All three of these traits are fundamental to their ability to function as the adaptive immune response to infectious agents, but concurrently render these cells vulnerable to transformation. Thus, it is classically considered that lymphomas arise at a relatively late stage in a lymphocyte's development during the process of modifying diversity within antigen receptors, and when the cell is capable of responding to stimulus via its receptor. Attempts to understand the aetiology of lymphoma have reinforced this notion, as the most notable advances to date have shown chronic stimulation of the antigen receptor by infectious agents or self-antigens to be key drivers of these diseases. Despite this, there is still uncertainty about the cell of origin in some lymphomas, and increasing evidence that a subset arises in a more immature cell. Specifically, a recent study indicates that T-cell lymphoma, in particular nucleophosmin-anaplastic lymphoma kinase-driven anaplastic large cell lymphoma, may originate in T-cell progenitors in the thymus. The Royal Society 2016-09-28 /pmc/articles/PMC5043587/ /pubmed/27683157 http://dx.doi.org/10.1098/rsob.160232 Text en © 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Malcolm, Tim I. M.
Hodson, Daniel J.
Macintyre, Elizabeth A.
Turner, Suzanne D.
Challenging perspectives on the cellular origins of lymphoma
title Challenging perspectives on the cellular origins of lymphoma
title_full Challenging perspectives on the cellular origins of lymphoma
title_fullStr Challenging perspectives on the cellular origins of lymphoma
title_full_unstemmed Challenging perspectives on the cellular origins of lymphoma
title_short Challenging perspectives on the cellular origins of lymphoma
title_sort challenging perspectives on the cellular origins of lymphoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043587/
https://www.ncbi.nlm.nih.gov/pubmed/27683157
http://dx.doi.org/10.1098/rsob.160232
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