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Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis

BACKGROUND: Rheumatoid arthritis (RA) is a condition associated with accelerated progression of atherosclerosis in affected individuals. Myocardial assessment using exercise testing in such patients, however, is often difficult to perform. Our objective was to determine the factors associated with s...

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Autores principales: Hromádka, Milan, Seidlerová, Jitka, Baxa, Jan, Suchý, David, Rajdl, Daniel, Šedivý, Jakub, Rokyta, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043604/
https://www.ncbi.nlm.nih.gov/pubmed/27686126
http://dx.doi.org/10.1186/s12872-016-0359-3
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author Hromádka, Milan
Seidlerová, Jitka
Baxa, Jan
Suchý, David
Rajdl, Daniel
Šedivý, Jakub
Rokyta, Richard
author_facet Hromádka, Milan
Seidlerová, Jitka
Baxa, Jan
Suchý, David
Rajdl, Daniel
Šedivý, Jakub
Rokyta, Richard
author_sort Hromádka, Milan
collection PubMed
description BACKGROUND: Rheumatoid arthritis (RA) is a condition associated with accelerated progression of atherosclerosis in affected individuals. Myocardial assessment using exercise testing in such patients, however, is often difficult to perform. Our objective was to determine the factors associated with severe coronary stenosis using computed tomography (CT) angiography of the coronary arteries in asymptomatic patients with RA. METHODS: Forty-four women with RA were examined using CT angiography to detect atherosclerotic involvement and significant coronary stenosis (>50 %). CT findings were correlated with the cardiovascular risk score, and with classical and most recent parameters of atherosclerosis. RESULTS: CT angiography of the coronary arteries revealed severe stenosis (>70 %) in 9 % of patients. High-sensitivity troponin I level was associated with severe coronary stenosis (odds ratio 6.37; 95 % confidence interval 1.53 − 26.48; P = 0.011). Adjustment for confounders did not alter this result (P = 0.039). In contrast, classical and modified Systemic Coronary Risk Evaluation scores had no value in predicting severe stenosis (P ≥ 0.49). CONCLUSION: The present study showed the possible benefits of a coronary CT angiography in women with RA and asymptomatic ischemic coronary heart disease. Increased levels of high-sensitivity troponin I may be a potential indication for this type of examination. However, further studies are needed to confirm these results.
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spelling pubmed-50436042016-10-05 Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis Hromádka, Milan Seidlerová, Jitka Baxa, Jan Suchý, David Rajdl, Daniel Šedivý, Jakub Rokyta, Richard BMC Cardiovasc Disord Research Article BACKGROUND: Rheumatoid arthritis (RA) is a condition associated with accelerated progression of atherosclerosis in affected individuals. Myocardial assessment using exercise testing in such patients, however, is often difficult to perform. Our objective was to determine the factors associated with severe coronary stenosis using computed tomography (CT) angiography of the coronary arteries in asymptomatic patients with RA. METHODS: Forty-four women with RA were examined using CT angiography to detect atherosclerotic involvement and significant coronary stenosis (>50 %). CT findings were correlated with the cardiovascular risk score, and with classical and most recent parameters of atherosclerosis. RESULTS: CT angiography of the coronary arteries revealed severe stenosis (>70 %) in 9 % of patients. High-sensitivity troponin I level was associated with severe coronary stenosis (odds ratio 6.37; 95 % confidence interval 1.53 − 26.48; P = 0.011). Adjustment for confounders did not alter this result (P = 0.039). In contrast, classical and modified Systemic Coronary Risk Evaluation scores had no value in predicting severe stenosis (P ≥ 0.49). CONCLUSION: The present study showed the possible benefits of a coronary CT angiography in women with RA and asymptomatic ischemic coronary heart disease. Increased levels of high-sensitivity troponin I may be a potential indication for this type of examination. However, further studies are needed to confirm these results. BioMed Central 2016-09-29 /pmc/articles/PMC5043604/ /pubmed/27686126 http://dx.doi.org/10.1186/s12872-016-0359-3 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Hromádka, Milan
Seidlerová, Jitka
Baxa, Jan
Suchý, David
Rajdl, Daniel
Šedivý, Jakub
Rokyta, Richard
Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis
title Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis
title_full Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis
title_fullStr Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis
title_full_unstemmed Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis
title_short Relationship between hsTnI and coronary stenosis in asymptomatic women with rheumatoid arthritis
title_sort relationship between hstni and coronary stenosis in asymptomatic women with rheumatoid arthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043604/
https://www.ncbi.nlm.nih.gov/pubmed/27686126
http://dx.doi.org/10.1186/s12872-016-0359-3
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