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A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia

CONTEXT: Oral premedication is widely used in pediatric anesthesia to provide preoperative anxiolysis and ensure smooth induction. Midazolam is currently the most commonly used premedicant, but newer drugs such as the α2-agonists have emerged as alternatives for premedication in children. AIMS: The...

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Autores principales: Jannu, V, Mane, RS, Dhorigol, MG, Sanikop, CS
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044721/
https://www.ncbi.nlm.nih.gov/pubmed/27833480
http://dx.doi.org/10.4103/1658-354X.177333
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author Jannu, V
Mane, RS
Dhorigol, MG
Sanikop, CS
author_facet Jannu, V
Mane, RS
Dhorigol, MG
Sanikop, CS
author_sort Jannu, V
collection PubMed
description CONTEXT: Oral premedication is widely used in pediatric anesthesia to provide preoperative anxiolysis and ensure smooth induction. Midazolam is currently the most commonly used premedicant, but newer drugs such as the α2-agonists have emerged as alternatives for premedication in children. AIMS: The aim of this study was to compare clinical effects of oral midazolam and oral dexmedetomidine on preanesthetic sedation and postoperative recovery profile in children. SETTINGS AND DESIGN: Randomized controlled trial. MATERIALS AND METHODS: We performed a prospective, randomized, controlled study in 60 children, aged 1-7 years undergoing elective, minor, lower abdominal surgeries under general anesthesia. Patients were randomly assigned to receive either oral midazolam 0.75 mg/kg (Group M, n = 30) or oral dexmedetomidine 4 μg/kg (Group D, n = 30) 40 min prior to mask induction. Preoperative sedation and anxiolysis, the response at parental separation, quality of mask acceptance and recovery profile were compared for the two groups. STATISTICAL ANALYSIS USED: Results were analyzed using unpaired Student's t-test and Chi-squared test. P < 0.05 was considered statistically significant. RESULTS: There was no significant difference in the levels of preoperative sedation and anxiolysis between the two groups, but the onset of sedation was significantly faster with midazolam (18.90 ± 3.68 min) than with dexmedetomidine (30.50 ± 4.44 min). Response to parental separation and quality of mask acceptance was comparable between two groups (P > 0.05). The incidence of postoperative agitation was significantly less in the dexmedetomidine group (P < 0.05). CONCLUSIONS: In this study, premedication with oral dexmedetomidine produced equally effective preoperative sedation and a better recovery from anesthesia in children in comparison to oral midazolam.
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spelling pubmed-50447212016-11-11 A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia Jannu, V Mane, RS Dhorigol, MG Sanikop, CS Saudi J Anaesth Original Article CONTEXT: Oral premedication is widely used in pediatric anesthesia to provide preoperative anxiolysis and ensure smooth induction. Midazolam is currently the most commonly used premedicant, but newer drugs such as the α2-agonists have emerged as alternatives for premedication in children. AIMS: The aim of this study was to compare clinical effects of oral midazolam and oral dexmedetomidine on preanesthetic sedation and postoperative recovery profile in children. SETTINGS AND DESIGN: Randomized controlled trial. MATERIALS AND METHODS: We performed a prospective, randomized, controlled study in 60 children, aged 1-7 years undergoing elective, minor, lower abdominal surgeries under general anesthesia. Patients were randomly assigned to receive either oral midazolam 0.75 mg/kg (Group M, n = 30) or oral dexmedetomidine 4 μg/kg (Group D, n = 30) 40 min prior to mask induction. Preoperative sedation and anxiolysis, the response at parental separation, quality of mask acceptance and recovery profile were compared for the two groups. STATISTICAL ANALYSIS USED: Results were analyzed using unpaired Student's t-test and Chi-squared test. P < 0.05 was considered statistically significant. RESULTS: There was no significant difference in the levels of preoperative sedation and anxiolysis between the two groups, but the onset of sedation was significantly faster with midazolam (18.90 ± 3.68 min) than with dexmedetomidine (30.50 ± 4.44 min). Response to parental separation and quality of mask acceptance was comparable between two groups (P > 0.05). The incidence of postoperative agitation was significantly less in the dexmedetomidine group (P < 0.05). CONCLUSIONS: In this study, premedication with oral dexmedetomidine produced equally effective preoperative sedation and a better recovery from anesthesia in children in comparison to oral midazolam. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5044721/ /pubmed/27833480 http://dx.doi.org/10.4103/1658-354X.177333 Text en Copyright: © Saudi Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Jannu, V
Mane, RS
Dhorigol, MG
Sanikop, CS
A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia
title A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia
title_full A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia
title_fullStr A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia
title_full_unstemmed A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia
title_short A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia
title_sort comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044721/
https://www.ncbi.nlm.nih.gov/pubmed/27833480
http://dx.doi.org/10.4103/1658-354X.177333
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