Cargando…

Can resistive breathing injure the lung? Implications for COPD exacerbations

In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to l...

Descripción completa

Detalles Bibliográficos
Autores principales: Vassilakopoulos, Theodoros, Toumpanakis, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044984/
https://www.ncbi.nlm.nih.gov/pubmed/27713628
http://dx.doi.org/10.2147/COPD.S113877
_version_ 1782457032656289792
author Vassilakopoulos, Theodoros
Toumpanakis, Dimitrios
author_facet Vassilakopoulos, Theodoros
Toumpanakis, Dimitrios
author_sort Vassilakopoulos, Theodoros
collection PubMed
description In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction). The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence.
format Online
Article
Text
id pubmed-5044984
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-50449842016-10-06 Can resistive breathing injure the lung? Implications for COPD exacerbations Vassilakopoulos, Theodoros Toumpanakis, Dimitrios Int J Chron Obstruct Pulmon Dis Commentary In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction). The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence. Dove Medical Press 2016-09-26 /pmc/articles/PMC5044984/ /pubmed/27713628 http://dx.doi.org/10.2147/COPD.S113877 Text en © 2016 Vassilakopoulos and Toumpanakis. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Commentary
Vassilakopoulos, Theodoros
Toumpanakis, Dimitrios
Can resistive breathing injure the lung? Implications for COPD exacerbations
title Can resistive breathing injure the lung? Implications for COPD exacerbations
title_full Can resistive breathing injure the lung? Implications for COPD exacerbations
title_fullStr Can resistive breathing injure the lung? Implications for COPD exacerbations
title_full_unstemmed Can resistive breathing injure the lung? Implications for COPD exacerbations
title_short Can resistive breathing injure the lung? Implications for COPD exacerbations
title_sort can resistive breathing injure the lung? implications for copd exacerbations
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044984/
https://www.ncbi.nlm.nih.gov/pubmed/27713628
http://dx.doi.org/10.2147/COPD.S113877
work_keys_str_mv AT vassilakopoulostheodoros canresistivebreathinginjurethelungimplicationsforcopdexacerbations
AT toumpanakisdimitrios canresistivebreathinginjurethelungimplicationsforcopdexacerbations