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Can resistive breathing injure the lung? Implications for COPD exacerbations
In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to l...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044984/ https://www.ncbi.nlm.nih.gov/pubmed/27713628 http://dx.doi.org/10.2147/COPD.S113877 |
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author | Vassilakopoulos, Theodoros Toumpanakis, Dimitrios |
author_facet | Vassilakopoulos, Theodoros Toumpanakis, Dimitrios |
author_sort | Vassilakopoulos, Theodoros |
collection | PubMed |
description | In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction). The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence. |
format | Online Article Text |
id | pubmed-5044984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50449842016-10-06 Can resistive breathing injure the lung? Implications for COPD exacerbations Vassilakopoulos, Theodoros Toumpanakis, Dimitrios Int J Chron Obstruct Pulmon Dis Commentary In obstructive lung diseases, airway inflammation leads to bronchospasm and thus resistive breathing, especially during exacerbations. This commentary discusses experimental evidence that resistive breathing per se (the mechanical stimulus) in the absence of underlying airway inflammation leads to lung injury and inflammation (mechanotransduction). The potential implications of resistive breathing-induced mechanotrasduction in COPD exacerbations are presented along with the available clinical evidence. Dove Medical Press 2016-09-26 /pmc/articles/PMC5044984/ /pubmed/27713628 http://dx.doi.org/10.2147/COPD.S113877 Text en © 2016 Vassilakopoulos and Toumpanakis. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Commentary Vassilakopoulos, Theodoros Toumpanakis, Dimitrios Can resistive breathing injure the lung? Implications for COPD exacerbations |
title | Can resistive breathing injure the lung? Implications for COPD exacerbations |
title_full | Can resistive breathing injure the lung? Implications for COPD exacerbations |
title_fullStr | Can resistive breathing injure the lung? Implications for COPD exacerbations |
title_full_unstemmed | Can resistive breathing injure the lung? Implications for COPD exacerbations |
title_short | Can resistive breathing injure the lung? Implications for COPD exacerbations |
title_sort | can resistive breathing injure the lung? implications for copd exacerbations |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044984/ https://www.ncbi.nlm.nih.gov/pubmed/27713628 http://dx.doi.org/10.2147/COPD.S113877 |
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