Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)

In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive oste...

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Detalles Bibliográficos
Autores principales: Dekoninck, J, Geurs, F, De Loecker, R, Deprest, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045002/
https://www.ncbi.nlm.nih.gov/pubmed/27774010
http://dx.doi.org/10.2147/POR.S15391
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author Dekoninck, J
Geurs, F
De Loecker, R
Deprest, Y
author_facet Dekoninck, J
Geurs, F
De Loecker, R
Deprest, Y
author_sort Dekoninck, J
collection PubMed
description In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.
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spelling pubmed-50450022016-10-21 Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX) Dekoninck, J Geurs, F De Loecker, R Deprest, Y Pragmat Obs Res Original Research In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX. Dove Medical Press 2011-07-27 /pmc/articles/PMC5045002/ /pubmed/27774010 http://dx.doi.org/10.2147/POR.S15391 Text en © 2011 Dekoninck et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Dekoninck, J
Geurs, F
De Loecker, R
Deprest, Y
Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
title Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
title_full Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
title_fullStr Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
title_full_unstemmed Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
title_short Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
title_sort significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum c telopeptide (ctx)
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045002/
https://www.ncbi.nlm.nih.gov/pubmed/27774010
http://dx.doi.org/10.2147/POR.S15391
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