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Complex role of HIF in cancer: the known, the unknown, and the unexpected

Tumor hypoxia has long been recognized as a driving force of malignant progression and therapeutic resistance. The discovery of hypoxia-inducible transcription factors (HIFs) has greatly advanced our understanding of how cancer cells cope with hypoxic stress by maintaining bioenergetics through the...

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Detalles Bibliográficos
Autores principales: Tiburcio, Patricia Denise, Choi, Hyunsung, Huang, L Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045057/
https://www.ncbi.nlm.nih.gov/pubmed/27774467
http://dx.doi.org/10.2147/HP.S50651