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Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges

Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged i...

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Autores principales: Harnoss, Jonathan Michael, Strowitzki, Moritz Johannes, Radhakrishnan, Praveen, Platzer, Lisa Katharina, Harnoss, Julian Camill, Hank, Thomas, Cai, Jun, Ulrich, Alexis, Schneider, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045068/
https://www.ncbi.nlm.nih.gov/pubmed/27774478
http://dx.doi.org/10.2147/HP.S60872
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author Harnoss, Jonathan Michael
Strowitzki, Moritz Johannes
Radhakrishnan, Praveen
Platzer, Lisa Katharina
Harnoss, Julian Camill
Hank, Thomas
Cai, Jun
Ulrich, Alexis
Schneider, Martin
author_facet Harnoss, Jonathan Michael
Strowitzki, Moritz Johannes
Radhakrishnan, Praveen
Platzer, Lisa Katharina
Harnoss, Julian Camill
Hank, Thomas
Cai, Jun
Ulrich, Alexis
Schneider, Martin
author_sort Harnoss, Jonathan Michael
collection PubMed
description Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients.
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spelling pubmed-50450682016-10-21 Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges Harnoss, Jonathan Michael Strowitzki, Moritz Johannes Radhakrishnan, Praveen Platzer, Lisa Katharina Harnoss, Julian Camill Hank, Thomas Cai, Jun Ulrich, Alexis Schneider, Martin Hypoxia (Auckl) Review Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients. Dove Medical Press 2015-01-30 /pmc/articles/PMC5045068/ /pubmed/27774478 http://dx.doi.org/10.2147/HP.S60872 Text en © 2015 Harnoss et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Harnoss, Jonathan Michael
Strowitzki, Moritz Johannes
Radhakrishnan, Praveen
Platzer, Lisa Katharina
Harnoss, Julian Camill
Hank, Thomas
Cai, Jun
Ulrich, Alexis
Schneider, Martin
Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
title Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
title_full Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
title_fullStr Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
title_full_unstemmed Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
title_short Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
title_sort therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045068/
https://www.ncbi.nlm.nih.gov/pubmed/27774478
http://dx.doi.org/10.2147/HP.S60872
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