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Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges
Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045068/ https://www.ncbi.nlm.nih.gov/pubmed/27774478 http://dx.doi.org/10.2147/HP.S60872 |
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author | Harnoss, Jonathan Michael Strowitzki, Moritz Johannes Radhakrishnan, Praveen Platzer, Lisa Katharina Harnoss, Julian Camill Hank, Thomas Cai, Jun Ulrich, Alexis Schneider, Martin |
author_facet | Harnoss, Jonathan Michael Strowitzki, Moritz Johannes Radhakrishnan, Praveen Platzer, Lisa Katharina Harnoss, Julian Camill Hank, Thomas Cai, Jun Ulrich, Alexis Schneider, Martin |
author_sort | Harnoss, Jonathan Michael |
collection | PubMed |
description | Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients. |
format | Online Article Text |
id | pubmed-5045068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50450682016-10-21 Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges Harnoss, Jonathan Michael Strowitzki, Moritz Johannes Radhakrishnan, Praveen Platzer, Lisa Katharina Harnoss, Julian Camill Hank, Thomas Cai, Jun Ulrich, Alexis Schneider, Martin Hypoxia (Auckl) Review Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients. Dove Medical Press 2015-01-30 /pmc/articles/PMC5045068/ /pubmed/27774478 http://dx.doi.org/10.2147/HP.S60872 Text en © 2015 Harnoss et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Harnoss, Jonathan Michael Strowitzki, Moritz Johannes Radhakrishnan, Praveen Platzer, Lisa Katharina Harnoss, Julian Camill Hank, Thomas Cai, Jun Ulrich, Alexis Schneider, Martin Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges |
title | Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges |
title_full | Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges |
title_fullStr | Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges |
title_full_unstemmed | Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges |
title_short | Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges |
title_sort | therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045068/ https://www.ncbi.nlm.nih.gov/pubmed/27774478 http://dx.doi.org/10.2147/HP.S60872 |
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