Genome Sequence Variability Predicts Drug Precautions and Withdrawals from the Market

Despite substantial premarket efforts, a significant portion of approved drugs has been withdrawn from the market for safety reasons. The deleterious impact of nonsynonymous substitutions predicted by the SIFT algorithm on structure and function of drug-related proteins was evaluated for 2504 person...

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Detalles Bibliográficos
Autores principales: Lee, Kye Hwa, Baik, Su Youn, Lee, Soo Youn, Park, Chan Hee, Park, Paul J., Kim, Ju Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045182/
https://www.ncbi.nlm.nih.gov/pubmed/27690231
http://dx.doi.org/10.1371/journal.pone.0162135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045182/
https://www.ncbi.nlm.nih.gov/pubmed/27690231
http://dx.doi.org/10.1371/journal.pone.0162135

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