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Genome Sequence Variability Predicts Drug Precautions and Withdrawals from the Market
Despite substantial premarket efforts, a significant portion of approved drugs has been withdrawn from the market for safety reasons. The deleterious impact of nonsynonymous substitutions predicted by the SIFT algorithm on structure and function of drug-related proteins was evaluated for 2504 person...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045182/ https://www.ncbi.nlm.nih.gov/pubmed/27690231 http://dx.doi.org/10.1371/journal.pone.0162135 |