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A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up

AIM: Earlier brain imaging research studies have suggested that brain abnormalities in obsessive-compulsive disorder (OCD) normalize as clinical symptoms improve. However, although many studies have investigated event-related potentials (ERPs) in patients with OCD compared with healthy control subje...

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Autores principales: Yamamuro, Kazuhiko, Okada, Koji, Kishimoto, Naoko, Ota, Toyosaku, Iida, Junzo, Kishimoto, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045237/
https://www.ncbi.nlm.nih.gov/pubmed/27713631
http://dx.doi.org/10.2147/NDT.S117100
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author Yamamuro, Kazuhiko
Okada, Koji
Kishimoto, Naoko
Ota, Toyosaku
Iida, Junzo
Kishimoto, Toshifumi
author_facet Yamamuro, Kazuhiko
Okada, Koji
Kishimoto, Naoko
Ota, Toyosaku
Iida, Junzo
Kishimoto, Toshifumi
author_sort Yamamuro, Kazuhiko
collection PubMed
description AIM: Earlier brain imaging research studies have suggested that brain abnormalities in obsessive-compulsive disorder (OCD) normalize as clinical symptoms improve. However, although many studies have investigated event-related potentials (ERPs) in patients with OCD compared with healthy control subjects, it is currently unknown whether ERP changes reflect pharmacological and psychotherapeutic effects. As such, the current study examined the neurocognitive components of OCD to elucidate the pathophysiological abnormalities involved in the disorder, including the frontal-subcortical circuits. METHODS: The Yale-Brown Obsessive-Compulsive Scale was used to evaluate 14 adult patients with OCD. The present study also included ten age-, sex-, and IQ-matched controls. The P300 and mismatch negativity (MMN) components during an auditory oddball task at baseline for both groups and after 1 year of treatment for patients with OCD were measured. RESULTS: Compared with controls, P300 amplitude was attenuated in the OCD group at Cz and C4 at baseline. Pharmacotherapy and psychotherapy treatment for 1 year reduced OCD symptomology. P300 amplitude after 1 year of treatment was significantly increased, indicating normalization compared with baseline at Fz, Cz, C3, and C4. We found no differences in P300 latency, MMN amplitude, or MMN latency between baseline and after one year of treatment. CONCLUSION: ERPs may be a useful tool for evaluating pharmacological and cognitive behavioral therapy in adult patients with OCD.
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spelling pubmed-50452372016-10-06 A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up Yamamuro, Kazuhiko Okada, Koji Kishimoto, Naoko Ota, Toyosaku Iida, Junzo Kishimoto, Toshifumi Neuropsychiatr Dis Treat Original Research AIM: Earlier brain imaging research studies have suggested that brain abnormalities in obsessive-compulsive disorder (OCD) normalize as clinical symptoms improve. However, although many studies have investigated event-related potentials (ERPs) in patients with OCD compared with healthy control subjects, it is currently unknown whether ERP changes reflect pharmacological and psychotherapeutic effects. As such, the current study examined the neurocognitive components of OCD to elucidate the pathophysiological abnormalities involved in the disorder, including the frontal-subcortical circuits. METHODS: The Yale-Brown Obsessive-Compulsive Scale was used to evaluate 14 adult patients with OCD. The present study also included ten age-, sex-, and IQ-matched controls. The P300 and mismatch negativity (MMN) components during an auditory oddball task at baseline for both groups and after 1 year of treatment for patients with OCD were measured. RESULTS: Compared with controls, P300 amplitude was attenuated in the OCD group at Cz and C4 at baseline. Pharmacotherapy and psychotherapy treatment for 1 year reduced OCD symptomology. P300 amplitude after 1 year of treatment was significantly increased, indicating normalization compared with baseline at Fz, Cz, C3, and C4. We found no differences in P300 latency, MMN amplitude, or MMN latency between baseline and after one year of treatment. CONCLUSION: ERPs may be a useful tool for evaluating pharmacological and cognitive behavioral therapy in adult patients with OCD. Dove Medical Press 2016-09-26 /pmc/articles/PMC5045237/ /pubmed/27713631 http://dx.doi.org/10.2147/NDT.S117100 Text en © 2016 Yamamuro et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Yamamuro, Kazuhiko
Okada, Koji
Kishimoto, Naoko
Ota, Toyosaku
Iida, Junzo
Kishimoto, Toshifumi
A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_full A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_fullStr A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_full_unstemmed A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_short A longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
title_sort longitudinal, event-related potential pilot study of adult obsessive-compulsive disorder with 1-year follow-up
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045237/
https://www.ncbi.nlm.nih.gov/pubmed/27713631
http://dx.doi.org/10.2147/NDT.S117100
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