Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations

The evolutionarily conserved Hippo inhibitory pathway plays critical roles in tissue homeostasis and organ size control, while mutations affecting certain core components contribute to tumorigenesis. Here we demonstrate that proliferation of Hippo pathway mutant human tumor cells exhibiting high con...

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Detalles Bibliográficos
Autores principales: Troilo, Albino, Benson, Erica K., Esposito, Davide, Garibsingh, Rachel-Ann A., Reddy, E. Premkumar, Mungamuri, Sathish Kumar, Aaronson, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045355/
https://www.ncbi.nlm.nih.gov/pubmed/27144834
http://dx.doi.org/10.18632/oncotarget.9117

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