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Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells
The cinobufagin (CB) has a broad spectrum of cytotoxicity to inhibit cell proliferation of various human cancer cell lines, but the molecular mechanisms still remain elusive. Here we observed that CB inhibited the cell proliferation and tumor growth, but induced cell cycle arrest and apoptosis in a...
Autores principales: | Zhang, Guangxin, Wang, Chao, Sun, Mei, Li, Jindong, Wang, Bin, Jin, Chengyan, Hua, Peiyan, Song, Ge, Zhang, Yifan, Nguyen, Lisa L.H., Cui, Ranji, Liu, Runhua, Wang, Lizhong, Zhang, Xingyi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045368/ https://www.ncbi.nlm.nih.gov/pubmed/26959116 http://dx.doi.org/10.18632/oncotarget.7898 |
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