Cargando…

Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein

We have previously characterized that FasL and Apo2L/TRAIL are stored in their bioactive form inside human T cell blasts in intraluminal vesicles present in multivesicular bodies. These vesicles are rapidly released to the supernatant in the form of exosomes upon re-activation of T cells. In this st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bosque, Alberto, Dietz, Lisa, Gallego-Lleyda, Ana, Sanclemente, Manuel, Iturralde, María, Naval, Javier, Alava, María Angeles, Martínez-Lostao, Luis, Thierse, Hermann-Josef, Anel, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045396/ https://www.ncbi.nlm.nih.gov/pubmed/27086912 http://dx.doi.org/10.18632/oncotarget.8678

Ejemplares similares

Role of Exosomes in the Regulation of T-Cell Mediated Immune Responses and in Autoimmune Disease
por: Anel, Alberto, et al.
Publicado: (2019)

Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy
por: Naval, Javier, et al.
Publicado: (2019)

Lipid Nanoparticles Decorated with TNF-Related Aptosis-Inducing Ligand (TRAIL) Are More Cytotoxic than Soluble Recombinant TRAIL in Sarcoma
por: Gallego-Lleyda, Ana, et al.
Publicado: (2018)

Double-Edged Lipid Nanoparticles Combining Liposome-Bound TRAIL and Encapsulated Doxorubicin Showing an Extraordinary Synergistic Pro-Apoptotic Potential
por: De Miguel, Diego, et al.
Publicado: (2019)

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
por: Pardo, Julián, et al.
Publicado: (2004)

Mutations in the ND2 Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells
por: Marco-Brualla, Joaquín, et al.
Publicado: (2019)

Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy
por: Ferrari, Veronica, et al.
Publicado: (2022)

DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL
por: Marco-Brualla, Joaquín, et al.
Publicado: (2023)

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
por: Ju, Jeong-Sun, et al.
Publicado: (2009)

Valosin-Containing Protein Gene Mutations: Cellular Phenotypes Relevant to Neurodegeneration
por: Poksay, Karen S., et al.
Publicado: (2011)

Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors
por: Bastola, Prabhakar, et al.
Publicado: (2019)

Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells
por: Kinzebach, Sven, et al.
Publicado: (2013)

Clinical Classification of Variants in the Valosin-Containing Protein Gene Associated With Multisystem Proteinopathy
por: Schiava, Marianela, et al.
Publicado: (2023)

Involvement of Peripheral and Central Nervous Systems in a Valosin-Containing Protein Mutation
por: Segers, Kurt, et al.
Publicado: (2014)

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
por: Fusser, Markus, et al.
Publicado: (2015)

Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophy
por: Zhou, Ning, et al.
Publicado: (2020)

Opium Induces Apoptosis in Jurkat Cells
por: Igder, Somayeh, et al.
Publicado: (2013)

Physiological Responses of Jurkat Lymphocytes to Simulated Microgravity Conditions
por: Morabito, Caterina, et al.
Publicado: (2019)

Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3
por: Laço, Mário N., et al.
Publicado: (2012)

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
por: Jiang, N, et al.
Publicado: (2013)

The valosin‐containing protein is a novel repressor of cardiomyocyte hypertrophy induced by pressure overload
por: Zhou, Ning, et al.
Publicado: (2017)

Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma
por: Rodriguez, Virginia, et al.
Publicado: (2019)

The Biogenesis of Dengue Virus Replication Organelles Requires the ATPase Activity of Valosin-Containing Protein
por: Mazeaud, Clément, et al.
Publicado: (2021)

Development of a standard of care for patients with valosin-containing protein associated multisystem proteinopathy
por: Korb, Manisha, et al.
Publicado: (2022)

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases
por: Chu, Siwei, et al.
Publicado: (2023)

Immunogenic Cell Death and Immunotherapy of Multiple Myeloma
por: Serrano-del Valle, Alfonso, et al.
Publicado: (2019)

Response: Commentary: Immunogenic Cell Death and Immunotherapy of Multiple Myeloma
por: Serrano Del Valle, Alfonso, et al.
Publicado: (2019)

Pathogenic variants of Valosin-containing protein induce lysosomal damage and transcriptional activation of autophagy regulators in neuronal cells
por: Ferrari, Veronica, et al.
Publicado: (2022)

Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells
por: Al-Saffar, N M S, et al.
Publicado: (2002)

Valosin-Containing Protein/p97 as a Novel Therapeutic Target in Acute Lymphoblastic Leukemia
por: Gugliotta, Gabriele, et al.
Publicado: (2017)

The valosin-containing protein is a novel mediator of mitochondrial respiration and cell survival in the heart in vivo
por: Lizano, Paulo, et al.
Publicado: (2017)

Targeting valosin‐containing protein enhances the efficacy of radiation therapy in esophageal squamous cell carcinoma
por: Luo, Hui, et al.
Publicado: (2019)

Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer †
por: Costantini, Susan, et al.
Publicado: (2021)

Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs
por: LeBlanc, Amy K., et al.
Publicado: (2022)

Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage
por: Kusaka, Mami, et al.
Publicado: (2022)

Immunoproteomic identification and characterization of Ni(2+)-regulated proteins implicates Ni(2+) in the induction of monocyte cell death
por: Jakob, Annika, et al.
Publicado: (2017)

Effect of Light Irradiation and Sex Hormones on Jurkat T Cells: 17β-Estradiol but Not Testosterone Enhances UVA-Induced Cytotoxicity in Jurkat Lymphocytes
por: Cohly, Hari H.P., et al.
Publicado: (2005)

SparkBLAST: scalable BLAST processing using in-memory operations
por: de Castro, Marcelo Rodrigo, et al.
Publicado: (2017)

Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant
por: Ayaki, Takashi, et al.
Publicado: (2014)

Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin‐containing protein inhibitor
por: Shikata, Yuki, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_femjj1v64ael8bh3at38jh9hsk