Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling

The binding of hepatocyte growth factor (HGF) to its receptor MET activates a signaling cascade that promotes cell survival, proliferation, cell scattering, migration and invasion of malignant cells. HGF is secreted by cancer cells or by tumor-associated fibroblasts as pro-HGF, an inactive precursor...

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Detalles Bibliográficos
Autores principales: Owusu, Benjamin Y., Bansal, Namita, Venukadasula, Phanindra K.M., Ross, Larry J., Messick, Troy E., Goel, Sanjay, Galemmo, Robert A., Klampfer, Lidija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045412/
https://www.ncbi.nlm.nih.gov/pubmed/27121052
http://dx.doi.org/10.18632/oncotarget.8785

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