X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response

Heat shock protein 90 (HSP90) is essential for cancer cells to assist the function of various oncoproteins, and it has been recognized as a promising target in cancer therapy. Although the HSP90 inhibitors in clinical trials have shown encouraging clinical efficacy, these agents induce heat shock re...

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Detalles Bibliográficos
Autores principales: Zhao, Zhixin, Zhu, Jianming, Quan, Haitian, Wang, Guimin, Li, Bo, Zhu, Weiliang, Xie, Chengying, Lou, Liguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045423/
https://www.ncbi.nlm.nih.gov/pubmed/27105490
http://dx.doi.org/10.18632/oncotarget.8818

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