CHIP: A new modulator of human malignant disorders

Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin–proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining pro...

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Detalles Bibliográficos
Autores principales: Cao, Zhe, Li, Guanqiao, Shao, Qianqian, Yang, Gang, Zheng, Lianfang, Zhang, Taiping, Zhao, Yupei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045438/
https://www.ncbi.nlm.nih.gov/pubmed/27007160
http://dx.doi.org/10.18632/oncotarget.8219
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author Cao, Zhe
Li, Guanqiao
Shao, Qianqian
Yang, Gang
Zheng, Lianfang
Zhang, Taiping
Zhao, Yupei
author_facet Cao, Zhe
Li, Guanqiao
Shao, Qianqian
Yang, Gang
Zheng, Lianfang
Zhang, Taiping
Zhao, Yupei
author_sort Cao, Zhe
collection PubMed
description Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin–proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining protein homeostasis in diverse conditions. Here, we provide a comprehensive review of our current understanding of CHIP and summarize recent advances in CHIP biology, with a focus on CHIP in the setting of malignancies.
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spelling pubmed-50454382016-10-13 CHIP: A new modulator of human malignant disorders Cao, Zhe Li, Guanqiao Shao, Qianqian Yang, Gang Zheng, Lianfang Zhang, Taiping Zhao, Yupei Oncotarget Review Carboxyl terminus of Hsc70-interacting protein (CHIP) is known as a chaperone-associated E3 for a variety of protein substrates. It acts as a link between molecular chaperones and ubiquitin–proteasome system. Involved in the process of protein clearance, CHIP plays a critical role in maintaining protein homeostasis in diverse conditions. Here, we provide a comprehensive review of our current understanding of CHIP and summarize recent advances in CHIP biology, with a focus on CHIP in the setting of malignancies. Impact Journals LLC 2016-03-20 /pmc/articles/PMC5045438/ /pubmed/27007160 http://dx.doi.org/10.18632/oncotarget.8219 Text en Copyright: © 2016 Cao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Cao, Zhe
Li, Guanqiao
Shao, Qianqian
Yang, Gang
Zheng, Lianfang
Zhang, Taiping
Zhao, Yupei
CHIP: A new modulator of human malignant disorders
title CHIP: A new modulator of human malignant disorders
title_full CHIP: A new modulator of human malignant disorders
title_fullStr CHIP: A new modulator of human malignant disorders
title_full_unstemmed CHIP: A new modulator of human malignant disorders
title_short CHIP: A new modulator of human malignant disorders
title_sort chip: a new modulator of human malignant disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045438/
https://www.ncbi.nlm.nih.gov/pubmed/27007160
http://dx.doi.org/10.18632/oncotarget.8219
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AT zhenglianfang chipanewmodulatorofhumanmalignantdisorders
AT zhangtaiping chipanewmodulatorofhumanmalignantdisorders
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