PXR variants: the impact on drug metabolism and therapeutic responses

The pregnane X receptor (PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters. Several protein isoforms of PXR exist, and they have differential transcriptional activity upon target genes; transcript variants 3 (PXR3) and 4 (PXR4) d...

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Detalles Bibliográficos
Autores principales: Brewer, C. Trent, Chen, Taosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045535/
https://www.ncbi.nlm.nih.gov/pubmed/27709012
http://dx.doi.org/10.1016/j.apsb.2016.07.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045535/
https://www.ncbi.nlm.nih.gov/pubmed/27709012
http://dx.doi.org/10.1016/j.apsb.2016.07.002

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