Isoniazid metabolism and hepatotoxicity

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations wit...

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Detalles Bibliográficos
Autores principales: Wang, Pengcheng, Pradhan, Komal, Zhong, Xiao-bo, Ma, Xiaochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045547/
https://www.ncbi.nlm.nih.gov/pubmed/27709007
http://dx.doi.org/10.1016/j.apsb.2016.07.014
Descripción
Sumario:Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.

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