Isoniazid metabolism and hepatotoxicity

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations wit...

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Detalles Bibliográficos
Autores principales: Wang, Pengcheng, Pradhan, Komal, Zhong, Xiao-bo, Ma, Xiaochao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045547/
https://www.ncbi.nlm.nih.gov/pubmed/27709007
http://dx.doi.org/10.1016/j.apsb.2016.07.014
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author Wang, Pengcheng
Pradhan, Komal
Zhong, Xiao-bo
Ma, Xiaochao
author_facet Wang, Pengcheng
Pradhan, Komal
Zhong, Xiao-bo
Ma, Xiaochao
author_sort Wang, Pengcheng
collection PubMed
description Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.
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spelling pubmed-50455472016-10-05 Isoniazid metabolism and hepatotoxicity Wang, Pengcheng Pradhan, Komal Zhong, Xiao-bo Ma, Xiaochao Acta Pharm Sin B Review Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury. Elsevier 2016-09 2016-08-03 /pmc/articles/PMC5045547/ /pubmed/27709007 http://dx.doi.org/10.1016/j.apsb.2016.07.014 Text en © 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Wang, Pengcheng
Pradhan, Komal
Zhong, Xiao-bo
Ma, Xiaochao
Isoniazid metabolism and hepatotoxicity
title Isoniazid metabolism and hepatotoxicity
title_full Isoniazid metabolism and hepatotoxicity
title_fullStr Isoniazid metabolism and hepatotoxicity
title_full_unstemmed Isoniazid metabolism and hepatotoxicity
title_short Isoniazid metabolism and hepatotoxicity
title_sort isoniazid metabolism and hepatotoxicity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045547/
https://www.ncbi.nlm.nih.gov/pubmed/27709007
http://dx.doi.org/10.1016/j.apsb.2016.07.014
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AT pradhankomal isoniazidmetabolismandhepatotoxicity
AT zhongxiaobo isoniazidmetabolismandhepatotoxicity
AT maxiaochao isoniazidmetabolismandhepatotoxicity

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