Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

We have shown recently that concurrent harmaline, a monoamine oxidase-A inhibitor (MAOI), potentiates serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-induced hyperthermia. The objective of this study was to develop an integrated pharmacokinetic/pharmacodynamic (PK/PD)...

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Detalles Bibliográficos
Autores principales: Jiang, Xi-Ling, Shen, Hong-Wu, Mager, Donald E., Schmidt, Stephan, Yu, Ai-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045556/
https://www.ncbi.nlm.nih.gov/pubmed/27709018
http://dx.doi.org/10.1016/j.apsb.2016.07.007

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