Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine

Intestine is responsible for the biotransformation of many orally-exposed chemicals. The constitutive androstane receptor (CAR/Nr1i3) is known to up-regulate many genes encoding drug-metabolizing enzymes and transporters (drug-processing genes/DPGs) in liver, but less is known regarding its effect i...

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Detalles Bibliográficos
Autores principales: Park, Shinhee, Cheng, Sunny Lihua, Cui, Julia Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045557/
https://www.ncbi.nlm.nih.gov/pubmed/27709017
http://dx.doi.org/10.1016/j.apsb.2016.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045557/
https://www.ncbi.nlm.nih.gov/pubmed/27709017
http://dx.doi.org/10.1016/j.apsb.2016.07.004

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