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Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine
Intestine is responsible for the biotransformation of many orally-exposed chemicals. The constitutive androstane receptor (CAR/Nr1i3) is known to up-regulate many genes encoding drug-metabolizing enzymes and transporters (drug-processing genes/DPGs) in liver, but less is known regarding its effect i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045557/ https://www.ncbi.nlm.nih.gov/pubmed/27709017 http://dx.doi.org/10.1016/j.apsb.2016.07.004 |