Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series

BACKGROUND: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus occurs through complex organ-specific cellular mechanisms and networks contributing to impaired insulin secretion and insulin resistance. Genome-wide gene expression profiling systems can disse...

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Detalles Bibliográficos
Autores principales: Dumas, Marc-Emmanuel, Domange, Céline, Calderari, Sophie, Martínez, Andrea Rodríguez, Ayala, Rafael, Wilder, Steven P., Suárez-Zamorano, Nicolas, Collins, Stephan C., Wallis, Robert H., Gu, Quan, Wang, Yulan, Hue, Christophe, Otto, Georg W., Argoud, Karène, Navratil, Vincent, Mitchell, Steve C., Lindon, John C., Holmes, Elaine, Cazier, Jean-Baptiste, Nicholson, Jeremy K., Gauguier, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045612/
https://www.ncbi.nlm.nih.gov/pubmed/27716393
http://dx.doi.org/10.1186/s13073-016-0352-6

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