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The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

BACKGROUND: The formation of new lymphatic vessels provides an additional route for tumour cells to metastasize. Therefore, inhibiting lymphangiogenesis represents an interesting target in cancer therapy. First evidence suggests that histone deacetylase inhibitors (HDACi) may mediate part of their a...

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Detalles Bibliográficos
Autores principales:	Hrgovic, Igor, Doll, Monika, Kleemann, Johannes, Wang, Xiao-Fan, Zoeller, Nadja, Pinter, Andreas, Kippenberger, Stefan, Kaufmann, Roland, Meissner, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045659/ https://www.ncbi.nlm.nih.gov/pubmed/27716272 http://dx.doi.org/10.1186/s12885-016-2807-y

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