Substantial inter-individual and limited intra-individual genomic diversity among tumors from men with metastatic prostate cancer

Intra-individual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases wit...

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Detalles Bibliográficos
Autores principales: Kumar, Akash, Coleman, Ilsa, Morrissey, Colm, Zhang, Xiaotun, True, Lawrence D., Gulati, Roman, Etzioni, Ruth, Bolouri, Hamid, Montgomery, Bruce, White, Thomas, Lucas, Jared M., Brown, Lisha G., Dumpit, Ruth F., DeSarkar, Navonil, Higano, Celestia, Yu, Evan Y., Coleman, Roger, Schultz, Nikolaus, Fang, Min, Lange, Paul H., Shendure, Jay, Vessella, Robert L., Nelson, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045679/
https://www.ncbi.nlm.nih.gov/pubmed/26928463
http://dx.doi.org/10.1038/nm.4053

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