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Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers

BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common condition that affects approximately 20% of the general population. The ulcers can interfere with speech and eating and cause significant pain and discomfort. This study aimed to evaluate the efficacy of Amlexanox and Adcortyl in the treatm...

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Autores principales: Abbasi, Farid, Raoof, Maryam, Khatami, Roya, Shadman, Niloofar, Borjian-Boroojeni, Farnaz, Nazari, Farahnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045682/
https://www.ncbi.nlm.nih.gov/pubmed/27703603
http://dx.doi.org/10.4317/jced.52540
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author Abbasi, Farid
Raoof, Maryam
Khatami, Roya
Shadman, Niloofar
Borjian-Boroojeni, Farnaz
Nazari, Farahnaz
author_facet Abbasi, Farid
Raoof, Maryam
Khatami, Roya
Shadman, Niloofar
Borjian-Boroojeni, Farnaz
Nazari, Farahnaz
author_sort Abbasi, Farid
collection PubMed
description BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common condition that affects approximately 20% of the general population. The ulcers can interfere with speech and eating and cause significant pain and discomfort. This study aimed to evaluate the efficacy of Amlexanox and Adcortyl in the treatment of aphthous ulcers. MATERIAL AND METHODS: In this randomized double blind clinical trial with sequential patient entry, a total of 40 patients who presented with aphthous ulcers were included. Patients were received Amlexanox or Adcortyl four times daily for 7 days. Patients were evaluated for pain, lesion size, and tingling at one day, three days, five days and seven days follow-ups. The treatment effects were then evaluated using the Wilcoxon–Mann–Whitney (WMW) test. Values of p<0.05 were considered significant. RESULTS: No significant differences in pain score, tingling and lesion size were observed on similar days between Amlexanox and Adcortyl groups. In both groups, reduction in the assessed variables was significant between days 1-3, 3-5, and 5-7 (p < 0.001). CONCLUSIONS: This study indicated that Amlexanox as well as Adcortyl was effective in relieving pain and reducing the lesion size during the treatment of aphthous ulcers. Key words:Recurrent aphthous stomatitis, Amlexanox, Adcortyl, pain relief.
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spelling pubmed-50456822016-10-04 Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers Abbasi, Farid Raoof, Maryam Khatami, Roya Shadman, Niloofar Borjian-Boroojeni, Farnaz Nazari, Farahnaz J Clin Exp Dent Research BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common condition that affects approximately 20% of the general population. The ulcers can interfere with speech and eating and cause significant pain and discomfort. This study aimed to evaluate the efficacy of Amlexanox and Adcortyl in the treatment of aphthous ulcers. MATERIAL AND METHODS: In this randomized double blind clinical trial with sequential patient entry, a total of 40 patients who presented with aphthous ulcers were included. Patients were received Amlexanox or Adcortyl four times daily for 7 days. Patients were evaluated for pain, lesion size, and tingling at one day, three days, five days and seven days follow-ups. The treatment effects were then evaluated using the Wilcoxon–Mann–Whitney (WMW) test. Values of p<0.05 were considered significant. RESULTS: No significant differences in pain score, tingling and lesion size were observed on similar days between Amlexanox and Adcortyl groups. In both groups, reduction in the assessed variables was significant between days 1-3, 3-5, and 5-7 (p < 0.001). CONCLUSIONS: This study indicated that Amlexanox as well as Adcortyl was effective in relieving pain and reducing the lesion size during the treatment of aphthous ulcers. Key words:Recurrent aphthous stomatitis, Amlexanox, Adcortyl, pain relief. Medicina Oral S.L. 2016-10-01 /pmc/articles/PMC5045682/ /pubmed/27703603 http://dx.doi.org/10.4317/jced.52540 Text en Copyright: © 2016 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Abbasi, Farid
Raoof, Maryam
Khatami, Roya
Shadman, Niloofar
Borjian-Boroojeni, Farnaz
Nazari, Farahnaz
Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers
title Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers
title_full Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers
title_fullStr Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers
title_full_unstemmed Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers
title_short Effectiveness of Amlexanox and Adcortyl for the treatment of recurrent aphthous ulcers
title_sort effectiveness of amlexanox and adcortyl for the treatment of recurrent aphthous ulcers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045682/
https://www.ncbi.nlm.nih.gov/pubmed/27703603
http://dx.doi.org/10.4317/jced.52540
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