The rules and impact of nonsense-mediated mRNA decay in human cancers

Premature termination codons (PTCs) cause a large proportion of inherited human genetic diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway termed nonsense-mediated mRNA decay (NMD). However, the efficiency of NMD varies; it is inefficient when a PTC is located downs...

Descripción completa

Detalles Bibliográficos
Autores principales: Lindeboom, Rik G.H., Supek, Fran, Lehner, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045715/
https://www.ncbi.nlm.nih.gov/pubmed/27618451
http://dx.doi.org/10.1038/ng.3664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045715/
https://www.ncbi.nlm.nih.gov/pubmed/27618451
http://dx.doi.org/10.1038/ng.3664

Ejemplares similares