Comparison of [(11)C]TZ1964B and [(18)F]MNI659 for PET imaging brain PDE10A in nonhuman primates

Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was to compare two potent and selective PDE10A ra...

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Detalles Bibliográficos
Autores principales: Liu, Hui, Jin, Hongjun, Yue, Xuyi, Han, Junbin, Yang, Hao, Flores, Hubert, Su, Yi, Alagille, David, Perlmutter, Joel S., Tamagnan, Gilles, Tu, Zhude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045939/
https://www.ncbi.nlm.nih.gov/pubmed/27713824
http://dx.doi.org/10.1002/prp2.253

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