Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection

Ionotropic activation of NMDA receptors (NMDARs) requires agonist glutamate and co-agonist glycine. Here we show that glycine enhances the activation of cell survival-promoting kinase Akt in cultured cortical neurons in which both the channel activity of NMDARs and the glycine receptors are pre-inhi...

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Detalles Bibliográficos
Autores principales: Hu, Rong, Chen, Juan, Lujan, Brendan, Lei, Ruixue, Zhang, Mi, Wang, Zefen, Liao, Mingxia, Li, Zhiqiang, Wan, Yu, Liu, Fang, Feng, Hua, Wan, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046082/
https://www.ncbi.nlm.nih.gov/pubmed/27694970
http://dx.doi.org/10.1038/srep34459

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