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Systemic Inhibition of CREB is Well-tolerated in vivo
cAMP-response element binding protein (CREB) is a nuclear transcription factor activated by multiple extracellular signals including growth factors and hormones. These extracellular cues activate CREB through phosphorylation at Ser133 by various protein serine/threonine kinases. Once phosphorylated,...
Autores principales: | Li, Bingbing X., Gardner, Ryan, Xue, Changhui, Qian, David Z., Xie, Fuchun, Thomas, George, Kazmierczak, Steven C., Habecker, Beth A., Xiao, Xiangshu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046085/ https://www.ncbi.nlm.nih.gov/pubmed/27694829 http://dx.doi.org/10.1038/srep34513 |
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